重庆医学Issue(1)：42-44,3.DOI:10.3969/j.issn.1671-8348.2015.01.014
强化他汀治疗对不稳定心绞痛患者自身免疫的影响
Impact of high-load atorvastatin on autoimmunity in patients with unstable angina
摘要
Abstract
Objective To explore the impact of high‐load atorvastatin on T cell subsets in patients with unstable angina (UA) after percutaneous coronary intervention (PCI) .Methods One hundred and eighty patients with UA were randomly divided into high‐load atorvastatin group ,ordinary‐load atorvastatin group and routine group ,60 cases in each group .The ratios of CD4+ T cell , CD8+ T cell and the frequencies of CD4+ CD25+ Treg were detected in 3 groups 1 day before PCI and 1 week ,1 month and 6 months after PCI by flow cytometry analysis .Results Different doses of atorvastatin reduced the ratio of CD4+ T cells and in‐creased the ratio of CD8+ T cells and also the frequencies of CD4+ CD25+ Treg after PCI for 1 week ,1 month and 6 months .The longer the time to take atorvastatin ,the more obvious the effect was(P<0 .05) .The ratios of CD4+ ,CD8+ T cells and the frequen‐cies of CD4+CD25+ Treg after PCI for 1 month and 6 months in high‐load atorvastatin showed significant difference compared with those in ordinary‐load atorvastatin group and routine group(P<0 .05) .Conclusion Atorvastatin could regulate the balance of T cell subsets in patients with UA ,and thus it may reduce the UA onset and the treatment effect of high‐load atorvastatin is more sig‐nificant .关键词
心绞痛 ,不稳定/T淋巴细胞/他汀Key words
angina ,unstable/T-Lymphocytes/atorvastatin分类
医药卫生引用本文复制引用
张静怡,张博男,李燕,穆怀彬,吕冰,张春来..强化他汀治疗对不稳定心绞痛患者自身免疫的影响[J].重庆医学,2015,(1):42-44,3.基金项目
唐山市科技支撑计划项目（12150222B-15）。 （）
