重庆医学Issue(1)：45-46,49,3.DOI:10.3969/j.issn.1671-8348.2015.01.015
舒芬太尼复合右美托咪定用于纤支镜引导清醒气管插管的对照研究
Comparative study of sufentanil combined with dexmedetomidine on the awake patients with fiber bronchoscope intubation
张云飞 1陈龙 1谭洪婧 1周满红2
作者信息
- 1. 贵州省遵义市第一人民医院麻醉科 563000
- 2. 遵义医学院附属医院特需病房，贵州遵义563000
- 折叠
摘要
Abstract
Objective To observe the effect of different doses of sufentanil on intubation guided by fiber bronchoscope in diffi‐cult airways .Methods One hundred and eighteen patients with difficult airways who underwent tracheal intubation were randomly divided into 3 groups [groupⅠ(n=40) ,groupⅡ (n=42) ,and groupⅢ (n=36)] .First all group received 1 μg/kg dexmedetomi‐dine ,then groupⅠ ,groupⅡ and group Ⅲ received sufentanil 0 .1μg/kg ,0 .2 μg/kg ,0 .3μg/kg infusion in bolus respectively .Heart rate(HR) ,mean arterial pressure(MAP)and saturation of pulse oximetry(SpO2 )were recorded at 5 min after patients arriving at operation room (T0 ) ,after drug infusion(T1 ) ,the time of intubation and seeing the epiglottis (T2 ) ,1 min(T3 )and 5 min(T4 )after intubation .side effect was recorded throughout the process .Results HR at T2 and T3 in groupⅡ and group Ⅲ were significantly lower than those in group Ⅰ(P<0 .05) .MAP at T2 and T3 in groupⅡ and group Ⅲ were significantly lower than those in groupⅠ(P<0 .05) .SpO2 at T2 in group Ⅲ was significantly lower than those of groupⅠ and groupⅡ(P<0 .05) .Cough reflex in groupⅠwas much frequent than others .Only group Ⅲ had respiratory inhibition .Conclusion Intravenous sufentanil (0 .2 μg/kg)could in‐hibit effectively stress reaction from endotracheal intubation ,in which less side effects such as haemodynamic changes and respirato‐ry depression occur .关键词
舒芬太尼/插管法,气管内/右美托咪定Key words
sufentanil/intubation ,intratracheal/dexmedetomidine分类
医药卫生引用本文复制引用
张云飞,陈龙,谭洪婧,周满红..舒芬太尼复合右美托咪定用于纤支镜引导清醒气管插管的对照研究[J].重庆医学,2015,(1):45-46,49,3.
