重庆医学Issue(2)：145-147,3.DOI:10.3969/j.issn.1671-8348.2015.02.001
抑郁复合皮肤创伤对创面微血管及成纤维细胞生长的影响
Effect of depression combined with skin injury on wound capillary angiogenesis and fibroblast growth
摘要
Abstract
Objective To explore the effect of depression combined with skin injury on wound capillary angiogenesis and fibro‐blast growth .Methods Totally 144 Sprague‐Dawley rats were randomly and equally divided into 3 groups:simple wound group ,de‐pression combined wound group ,wound combined depression group ,48 mice in each of the 3 groups .Immunohistochemical staining was used to label vascular endothelial cell and fibroblast with CD34 and Vimentin antibody respectively ,then counted by the high resolution microscope .Results Compared with other 2 groups ,the number of micro vascular and fibroblast in the wound granula‐tion tissue were lower in depression combined with mechanical skin injury group at the first stage(3 days after injury)(P<0 .05) , and faded more slowly in the later stage(at the 21st day)(P>0 .05) .There was significant difference between 3 groups in the num‐ber of fibroblast during the 18th day and 21st day(P<0 .05) .Conclusion Depression combined with skin injury could significantly inhibit the capillary angiogenesis and fibroblast growth in the wound granulation tissue ,thereby delaying wound healing .关键词
抑郁/成纤维细胞/微血管/创面愈合Key words
depression/fibroblast/microvessel/wound healing分类
医药卫生引用本文复制引用
周明芳,程天民,冯正直..抑郁复合皮肤创伤对创面微血管及成纤维细胞生长的影响[J].重庆医学,2015,(2):145-147,3.基金项目
军队“十一五”科技攻关项目（06G076）。 （）
