重庆医学Issue(4)：453-455,3.DOI:10.3969/j.issn.1671-8348.2015.04.007
葡萄皮渣中原花青素对临床常见分离菌的抗菌效应分析
Antibacterial effect of grape peel procyani residudins on common clinical bacteria
摘要
Abstract
Objective To investigate the antibacterial effect of grape peel residue procyanidins on common clinical bacteria ,inclu‐ding E .coli ,Pseudomonas aeruginosa ,Acinetobacter baumannii ,Enterococcus and methicillin‐resistant Staphylococcus aureus (M R‐SA) .Methods By the means of agar plate method ,we detected the minimum inhibitory concentration (MIC) of 30 strains of E .co‐li ,28 strains of Pseudomonas aeruginosa ,15 strains of Acinetobacter baumannii ,32 strains of Feces Enterococcus ,25 strains of E . faecalis and 70 strains of MRSA ,then calculate the MIC50 and MIC90 .The result was analyzed with SPSS software 16 .0 .Results The concentration of procyanidins at 3 -8 mg/mL had no inhibitory effect on E .coli ,Pseudomonas aeruginosa and Acinetobacter baumannii;there was no inhibitory effect on E .faecalis at 3-8 mg/mL ,but the inhibition rate to Feces Enterococcus was 6 .3% .By measuring the inhibitory effect of procyanidins on 70 MRSA ,the inhibition rate at 4 mg/mL was 65 .7% ,at 8 mg/mL was 95 .7% , MIC50 was 4 .221 mg/mL and MIC90 was 6 .260 mg/mL .Conclusion There are no inhibitory effects of grape peel residue procya‐nidins on Gram‐negative bacilli such as E .coli ,Pseudomonas aeruginosa ,Acinetobacter baumannii ,and there are certain inhibitory effects on Gram‐positive bacteria such as MRSA ,enterococci ,especially on MRSA (P<0 .05) .关键词
原花青素类/耐甲氧西林金黄色葡萄球菌/最低抑菌浓度Key words
procyanidins/methicillin-resistant Saureus/minimum inhibitory concentration分类
医药卫生引用本文复制引用
方莉,王静,许媛,蔡燕,廖涛,唐中..葡萄皮渣中原花青素对临床常见分离菌的抗菌效应分析[J].重庆医学,2015,(4):453-455,3.基金项目
四川省卫生厅科研课题（120437）。 （）
