重庆医学Issue(6)：813-815,3.DOI:10.3969/j.issn.1671-8348.2015.06.034
1160例孕早期绒毛染色体细胞遗传学分析
Analysis of fetal chromosomal karyotypes in 1 160 pregnant women during the first trimester of gestation
摘要
Abstract
Objective To evaluate the value of chorionic villus cells karyotype analysis in prenatal diagnosis during the first tri-mester of pregnancy.Methods Pregnant women with prenatal diagnosis indications were punctured by guiding abdominal B-mode ultrasound to get villi tissue which was then to develop cell culture,chromosome preparation and karyotype analysis.Results A to-tal of 1 140 cases were successfully cultured,and the successful cultivating rate was 98.2% (1 140/1 160).Among them,chromo-somes of 62 cases were detected to be non-polymorphic structural abnormalities,including 32 abnormal chromosome number,5 chro-mosome balanced translocation,3 chromosome deletion,and 22 chimeras.What′s more,20 cases were detected to be chromosomal inversion,19 cases of chromosome 9 were inversion,and one with chromosome Y was inversion.Conclusion Karyotype analysis of villus cell could help to detect fetal chromosomal abnormalities during early pregnancy and get early intervention.It was significant to reduce the child′s birth with chromosome abnormalities.关键词
产前诊断/核型分析/早孕期/绒毛细胞Key words
prenatal diagnosi/karyotype analysis/first trimester/chorionic villus cells分类
医药卫生引用本文复制引用
欧阳鲁平,陈少科,费冬梅,刘天盛,黄红倩,郑陈光..1160例孕早期绒毛染色体细胞遗传学分析[J].重庆医学,2015,(6):813-815,3.基金项目
十二五国家科技支撑计划项目两项（2012BAI09B04）。 （）
