重庆医学Issue(7)：878-880,3.DOI:10.3969/j.issn.1671-8348.2015.07.005
乳腺癌 GPR30、HRG1和 HER2表达与淋巴结转移关系的研究
Expression of GPR30,HRG1 and HER2 in breast cancer and their relationship with lymphatic metastasis
摘要
Abstract
Objective To explore the expression of GPR30,HRG1 and HER2 including the activation status of HER2 (phosphorylated HER2)in invasive ductal breast cancers and their relationship with lymphatic metastasis.Methods The expres-sion of GPR30,HRG1,HER2 and pHER2 in 72 cases of specimens of invasive ductal breast cancers were examined by immunohis-tochemistry method.Results A moderate correlation between GPR30 and HRG1 was disclosed (r=0.597,P =0.000).There was strong correlation between pHER2 and GPR30 or HRG1(r=0.742,P =0.000;r=0.615,P =0.000).The expression of GPR30 and pHER2 in the lymphatic metastasis group was remarkably higher than in the group without lymphatic metastasis(P <0.05). Conclusion The interaction between GPR30 and HRG1 HER2 signal transduction pathways might be involved in the lymphatic metastasis in breast cancer.Blocking both of GPR30 and HRG1 signaling pathway could be a promising new strategy for breast cancer treatments.关键词
乳腺肿瘤/淋巴转移/G蛋白偶联受体30/HRG1/HER2Key words
breast neoplasms/lymphatic metastasis/GPR30/HRG1/HER2分类
医药卫生引用本文复制引用
阮姝琴,李刚,王善伟,韩萍,杨志祥..乳腺癌 GPR30、HRG1和 HER2表达与淋巴结转移关系的研究[J].重庆医学,2015,(7):878-880,3.基金项目
重庆市卫生局医学科研项目（2013-2-111）；陕西省教育厅自然科学研究项目（12JK0709）。 （）
