重庆医学Issue(7)：885-887,3.DOI:10.3969/j.issn.1671-8348.2015.07.007
纳米羟基磷灰石／聚酰胺66／富血小板血浆复合物修复兔股骨中段骨缺损的实验研究
The experimental research of nano-hydroxyapatite/polyamide 66/platelet-rich plasma compound repair of rabbit femoral bone defect
摘要
Abstract
Objective To investigate the therapeutic effects of nano-hydroxyapatite/polyamide 66/platelet-rich plasma com-pound(n-HA/PA66/PRP)on the recovery of rabbit femur bone defect.Methods 40 New Zealand rabbits were artificially made to be bone defect by resecting the 1 cm substantia ossea with periosteum of femur,and were divided into two groups averagely depen-ding on implanted materials:experimental group(n-HA/PA66/PRP),control group (n-HA/PA66).Every five rabbits were sacri-ficed on week 2,4,8,12,and the femur healing status was observed by X ray,histology,and immunohistochemistry.Results No rabbit was infected or died,no implantation objects dropped.Gross observation,X-ray result and histology results demonstrated that the experimental group began to have a new bone tissue at 2 weeks after the operation,with the extension of time,the experimental group new bone growth speed and the quantity was better than the control group.The Lane-Sandhu method X-ray score showed that the experimental group (6.80±2.05)points and the control group(4.20±1.30)points at 12 weeks after the operation,and there were significant differences between two groups(P <0.05).Immunohistochemistry indicated that expression intensity of Vas-cular endothelial growth factor at 2 weeks and 4 weeks were significant differences between two groups(P <0.05),but there was no significant difference at 8 weeks and 12 weeks (P >0.05).Conclusion PRP combined with n-HA/PA66 artificial bone could accel-erate the healing of bone defect,and the effect of repair of bone defect is better than that of n-HA/PA66 artificial bone in the early.关键词
骨缺损/富血小板血浆/纳米羟基磷灰石/聚酰胺66Key words
bone defect/platelet-rich plasma/nano-hydroxyapatite/polyamide 66分类
医药卫生引用本文复制引用
卢旻鹏,王群波,董靖,曹春风,邱皓,朱水涛,刘佐忠,焦春艳..纳米羟基磷灰石／聚酰胺66／富血小板血浆复合物修复兔股骨中段骨缺损的实验研究[J].重庆医学,2015,(7):885-887,3.基金项目
重庆市教委科学技术研究基金资助项目（KJ120316）；重庆医科大学附属永川医院人才引进课题基金资助项目（YJYJ2011004）。 （）
