重庆医学Issue(7)：907-909,912,4.DOI:10.3969/j.issn.1671-8348.2015.07.015
纳米炭吸附多西紫杉醇在乳腺癌区域淋巴化疗中的临床研究
Nano carbon adsorption taxotere clinical research in regional lymphatic chemotherapy of breast cancer
摘要
Abstract
Objective To explore the nano carbon adsorption taxotere(TAX-CNP)of the lymph node chemotherapy drug targeting property.Methods The lymph node targeted chemotherapy experimental group(A group):Injection of 1 mL taxotere (TAX)plus 1 mL carbon nanoparticles(CNP),average four groups,preoperative on 12,24,36 and 48 h,the lymph node targeted chemotherapy of TAX-CNP before surgery;peripheral venous chemotherapy in the control group(B group):intravenous infusion with 1 mL TAX of 0.9% sodium chloride solution 100 mL,average four groups,according to the same point in time the peripheral intravenous doses of the same TAX.Gather the axillary lymph nodes after the surgery,used high performance liquid chromatograph tests the content of TAX in the two groups of lymph nodes;TUNEL method and flow cytometry instrument detect cell apoptosis, which are carcinoma metastasis lymph nodes of Two groups.Results (1)lymph node TAX level of group A was significant higher than group B(P <0.05);(2)Cell apoptosis index(AI)and apoptosis rate of A1 group were lower than that in group A2,A3,A4(P<0.05),in the cell AI and apoptosis rate of A2,A3,A4 group had no statistically significant difference(P <0.05);(3)Cells AI and apoptosis rate of cancer metastasis lymph node of Group A were significant higher than group B(P <0.05).Conclusion TAX-CNP can significantly increase the drug concentration of lymph nodes,which have better lymphatic targeting property;Preoperative 24 h injection is a more ideal injection time;TAX-CNP can obviously increase the metastasis lymph cell apoptosis,which can reduce short-term recurrence rate.关键词
乳腺肿瘤/淋巴化疗/纳米炭/多西紫杉醇Key words
breast tumor/lymphatic chemotherapy/nano-carbon/taxotere分类
医药卫生引用本文复制引用
李伟,曾晓华,徐发良,熊忠讯,罗杰..纳米炭吸附多西紫杉醇在乳腺癌区域淋巴化疗中的临床研究[J].重庆医学,2015,(7):907-909,912,4.基金项目
重庆市卫生局基金资助项目（2012-2-490）。 （）
