重庆医学Issue(9)：1165-1167,3.DOI:10.3969/j.issn.1671-8348.2015.09.004
细胞周期调控因子P16INK4、P57kip2和K i67在肝癌中的表达及意义
Expression and significance of P16INK4,P57kip2 and Ki67 in hepatocellular carcinoma
摘要
Abstract
Objective Analysis the expression and significance of P16INK4 ,P57kip2 and Ki67 in hepatocellular carcinoma .Meth-ods 21 normal liver tissue ,48 hepatocellular carcinoma tissues and 48 corresponding adjacent tissue were collected for this study . Immunohistochemical analysis the expression levels of P16INK4 ,P57kip2 and Ki67 .Results P16INK4 and P57kip2 in hepatocellular carci-noma tissue were significantly lower ,the positive rates were 49 .3% and 34 .2% respectively ,Ki67 was significantly higher than the normal liver tissue and corresponding adjacent tissue ,the difference was statistically significant(P<0 .05) ,the results were consist-ent with the Western blot ;different differentiated group p57kip2 ,Ki67 expression and P16INK4 were significant differences(P<0 .05) . Conclusion Low expression of P16INK4 and P57kip2 ,the higher expression of Ki67 play an important role in the development of hepa-tocellular carcinoma .关键词
P16INK4/P57kip2/Ki67/肝癌Key words
P16INK4/P57kip2/Ki67/hepatocellular carcinoma分类
医药卫生引用本文复制引用
高涵,周涛,张春晶,李淑艳,王丽萍,刘哲丞..细胞周期调控因子P16INK4、P57kip2和K i67在肝癌中的表达及意义[J].重庆医学,2015,(9):1165-1167,3.基金项目
黑龙江省齐齐哈尔市科学技术计划基金资助项目（SFGG-201338）。 （）
