重庆医学Issue(9)：1177-1179,1183,4.DOI:10.3969/j.issn.1671-8348.2015.09.008
非小细胞肺癌 EGFR基因突变与ERCC1、TYMS mRNA表达相关性的研究
Correlation of EGFR mutation with ERCC1 and TYMS mRNA expression in non-small cell lung cancer
摘要
Abstract
Objective To investigate whether EGFR gene mutations are correlated with the gene expression of ERCC1 and TYMS in non-small-cell lung cancer .Methods Collected February to December 2013 of non-small cell lung cancer(NSCLC) pa-tients eligible for enrolled 97 patients ,tumor tissue specimens obtained by intraoperative cut or puncture ,Gene expression of ERCC1 and TYMS were determined by branched-DNA liquid chip ,while somatic mutations in EGFR(E18 ,E19 ,E20 ,E21) gene were detec-ted by xTAG-liquid chip;And analysis of EGFR gene mutation associated with ERCC1 ,TYMS mRNA expression .Results Totally 29 cases of EGFR mutation were detected in all 97 specimens ,with a mutation rate of 30% (29/97) ,and a relatively high detection rate was observed in female ,adenocarcinoma and non-smoking patients(P<0 .05) .EGFR mutation was relevant to the expression of ERCC1(χ2 =4 .088 ,P<0 .05) ,EGFR mutation was irrelevant to the expression of TYMS(χ2 =0 .265 ,P>0 .05) .Conclusion In NSCLC tissues ,EGFR mutation is relevant to the expression of ERCC1 but irrelevant to the expression of TYMS .关键词
非小细胞肺癌/核苷酸切除修复交叉互补基因1/胸苷酸合成酶/表皮生长因子受体Key words
non-small cell lung cancer/ERCC1/TYMS/EGFR分类
医药卫生引用本文复制引用
张全,蒋彬,谭群友,王如文,陶绍霖,康珀铭,邓波,周景海,李坤,钱凯..非小细胞肺癌 EGFR基因突变与ERCC1、TYMS mRNA表达相关性的研究[J].重庆医学,2015,(9):1177-1179,1183,4.基金项目
国家自然科学基金资助项目（81172239）。 （）
