重庆医学Issue(10)：1330-1333,4.DOI:10.3969/j.issn.1671-8348.2015.10.012
叶酸代谢相关酶基因多态性与不良孕产发生易感性的关系
Relationship between folic acid metabolism-related enzyme gene polymorphism and susceptibility of abnormal pregnancy
摘要
Abstract
Objective To analyze the relationship between methylenetetrahydrofolate reductase (MTHFR)C677T,A1298C and methionine synthase reductase(MTRR)gene polymorphism with abnormal pregnancy history.Methods 549 normal women (control group)and 300 women with the abnormal pregnancy history(observation group)were taken as the subjects by adopting the case control research method.The oral mucosa epithelial cells were collected for extracting genomic DNA.The MTHFR and MTRR gene polymorphisms were detected by the gene sequencing method.Results The distribution frequency of MTHFR 677TT genotype in the abnormal pregnancy group was significantly increased compared with the control group (10.00% vs.3.46%,χ2 =15.25,P <0.01);the distribution frequency of MTHFR-1298CC genotype in the abnormal pregnancy group was significantly in-creased compared with the control group (11.00 vs.4.01%,χ2 =15.66,P <0.01);the distribution frequency of MTRR A66G gen-otype had no statistical difference between the two groups(χ2 =3.02,P =0.082).The interactive analysis of 2 genes indicated that simultaneous carrying the MTHFR A1298C mutation site and MTRR A66G mutation site increased the possibility of abnormal pregnancy occurrence (OR=1.52,P =0.011).Conclusion MTHFR C677T and A1298C have a certain correlation with female ab-normal pregnancy occurrence.关键词
亚甲基四氢叶酸还原酶/甲硫氨酸合成酶还原酶/不良孕产史/基因多态性Key words
methylenetetrahydrofolate reductase/methionine synthase reductase/abnormal pregnancy history/gene polymor-phism分类
医药卫生引用本文复制引用
李茜西,伍萍芝,何琳琳,吕德欣,傅锦坚..叶酸代谢相关酶基因多态性与不良孕产发生易感性的关系[J].重庆医学,2015,(10):1330-1333,4.基金项目
广西医药卫生自筹经费资助项目（Z2014373）。 （）
