重庆医学Issue(10)：1364-1366,3.DOI:10.3969/j.issn.1671-8348.2015.10.024
MMP-14蛋白在胃癌侵袭转移中的表达和作用
Expression and role of MMP-14 protein in invasion and metastasis of stomach carcinoma
谷倬宇 1李思源 2肖智伟 1周婷 1李军1
作者信息
- 1. 石河子大学医学院第一附属医院
- 2. 新疆地方与民族高发病教育部重点实验室，新疆石河子 832002
- 折叠
摘要
Abstract
Objective To explore the expression of matrix metalloproteinase-14(MMP-14)protein in the human stomach carcinoma tissues and its correlation with carcinoma invasiveness and metastasis.Methods The MMP-14 protein expression was detected by immunohistochemistry in 59 cases of stomach carcinoma tissues (observation group)and 20 cases of normal stomach tissues (control group,the adjacent normal tissues from the tumor margin of 5 cm confirmed by pathology),and its correlation with the clinically pathological parameters was analyzed.The expression characteristics of MMP-14 among various TNM stages of stom-ach carcinoma were also analyzed.Results The positive rate of MMP-14 expression was 50.85%(30/59)in the observation group and 5.00% (1/20)in the control group,the positive rate of the observation group was significantly higher than that of the control group (P <0.01);the expression level of MMP-14 was correlated with the differentiation degree,regional lymph node metastasis degree,invasion depth,lymphatic invasion and TNM stage,which showing the statistical difference(P < 0.01);the expression of MMP-14 protein was up-regulated and showed the transferring trend from cytoplasm to cellular membrane along with the progres-sion of TNM stage.Conclusion The overexpression of MMP-14 protein exists in stomach carcinoma tissues,which contributing to the invasion and metastasis of stomach carcinoma cells.关键词
胃肿瘤/基质金属蛋白酶14/肿瘤浸润/肿瘤转移/免疫组织化学Key words
stomach neoplasms/matrix metalloproteinase 14/neoplasm invasiveness/neoplasm metastasis/immunohisto-chemistry分类
医药卫生引用本文复制引用
谷倬宇,李思源,肖智伟,周婷,李军..MMP-14蛋白在胃癌侵袭转移中的表达和作用[J].重庆医学,2015,(10):1364-1366,3.
