重庆医学Issue(14)：1897-1899,1901,4.DOI:10.3969/j.issn.1671-8348.2015.14.009
动态动脉硬化指数与高血压靶器官损伤的相关性及动态观察
Correlation and dynamic observation of ambulatory arterial stiffness index and target organ damage of hypertension
摘要
Abstract
Objective To observe the changes of ambulatory arterial stiffness index (AASI) and target organ damage (TODs) after antihypertensive treatment in hypertensive patients .Methods A total of 300 cases of newly diagnosed hypertension were screened out and after strictly controlling blood pressure ,completed the ambulatory blood pressure and target organ damage inspection by 1‐year follow‐up .The dynamic changes of AASI and target organ damage were observed .Results After 1‐year anti‐hypertensive therapy ,AASI showed the gradually descending trend ,compared with before treatment ,began to decline at 6 months , decreased significantly after 1 year ;AASI showed the independent positive correlation with the intima‐media thickness(IMT) of ca‐rotid artery ,urine microalbumin(UMA) ,renal vascular resistance index(RRI) and left ventricular mass index(LVMI) ,and inde‐pendent negative correlation with endogenous creatinine clearance rate(Ccr) before and after treatment ;the multiple linear regres‐sion analysis showed that IMT ,UMA ,RRI ,Ccr and LVMI had significant correlation with AASI .After 1 year of therapy ,IMT , UMA ,RRI ,Ccr ,LVMI had shown some improvement(P<0 .05) .Conclusion AASI can be used as an indicator for evaluating arte‐riosclerosis and predicting the target organ damage in hypertension .关键词
高血压/动态动脉硬化指数/颈动脉内-中膜厚度/尿微量清蛋白/肾血管阻力指数Key words
hypertension/ambulatory arterial stiffness index/carotid intima-media thickness/urinary microalbumin/renal vascular resistant indices分类
医药卫生引用本文复制引用
高金全,李俊峰,刘瑶,张亚西,王安伟..动态动脉硬化指数与高血压靶器官损伤的相关性及动态观察[J].重庆医学,2015,(14):1897-1899,1901,4.基金项目
四川省卫生厅科研计划项目（120459）。 （）
