重庆医学Issue(14)：1924-1927,4.DOI:10.3969/j.issn.1671-8348.2015.14.020
IL-1RN-2018多态性及IL-1Ra／IL-1β比值与非小细胞肺癌的关系
Association between IL-1RN-2018 gene polymorphism and IL-1Ra/IL-1βwith non-small cell lung cancer
李君蕊 1肖颖 2付盈菊 3张雅丽 1卢玉娟 4亢瑞娜 1赵宝春1
作者信息
- 1. 河北医科大学附属唐山工人医院 感染科 063000
- 2. 河北医科大学附属唐山工人医院 肿瘤内科 063000
- 3. 河北医科大学附属唐山工人医院 急诊内科 063000
- 4. 河北医科大学附属唐山工人医院 检验科 063000
- 折叠
摘要
Abstract
Objective To investigate the association between interleukin receptor antagonist (IL‐1Ra) encoded genes(IL‐1RN‐2018) polymorphisms and serum IL‐1Ra/IL‐1β with non‐small cell lung cancer (NSCLC ) .Methods Totally 85 cases of NSCLC were selected as the NSCLC group and 80 cases of healthy physical examination were selected as the control group from January 2012 to January 2014 .The IL‐1RN‐2018 T/C gene polymorphisms of the two groups were determined with the fluorescence quantitative PCR technique based on high resolution melting ,10% randomly selected samples were sequenced to prove the accura‐cy .The levels of IL‐1Ra and IL‐1βof two groups were determined with ELISA .Results (1)The onset risk of NSCLC in TC and TC+CC genotypes on IL‐1RN‐2018 site in the NSCLC group were increased by 2 .646 times and 2 .315 times respectively compared with TT genotype ,the difference had statistical significance(P<0 .05) .(2)No statistically significant difference of IL‐1RN‐2018 T/C were found between patients with squamous cell carcinoma and adenocarcinomas(P>0 .05) .(3)The serum IL‐1Ra and IL‐1βlev‐els in the NSCLC group were significantly higher than those in the control group ,but IL‐1Ra/IL‐1βin the NSCLC group was signif‐icantly lower (P<0 .05) .(4)The serum IL‐1Ra levels in the NSCLC group had no statistically significant difference among geno‐types (P>0 .05) .Conclusion The C allele in IL‐1RN‐2018 site may increase the onset risk of NSCLC ;the reduction of serum IL‐1Ra/IL‐1βmay presage the risk of NSCLC .关键词
白细胞介素1受体拮抗剂/白细胞介素1β/基因多态性/癌 ,非小细胞肺Key words
interleukin 1 receptor antagonist/interleukin 1 bata/polymorphism/carcinoma ,non-small cell lung分类
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李君蕊,肖颖,付盈菊,张雅丽,卢玉娟,亢瑞娜,赵宝春..IL-1RN-2018多态性及IL-1Ra／IL-1β比值与非小细胞肺癌的关系[J].重庆医学,2015,(14):1924-1927,4.
