重庆医学Issue(14)：1934-1935,1938,3.DOI:10.3969/j.issn.1671-8348.2015.14.023
甲状腺自身抗体与复发性流产的相关性分析
Analysis on correlation between thyroid autoantibodies with recurrent abortion
纪邦群 1杨玉林 1郑丽波 1吴世木 1郭玲 1刘成华 1王常梅 1黄蓓蓓1
作者信息
- 1. 贵州省兴义市人民医院内分泌科 562400
- 折叠
摘要
Abstract
Objective To study the correlation between thyroid autoantibodies anti‐thyroid peroxidase antibody (TPOAb) with recurrent miscarriage to seek the objective data indicator for clinical diagnosis of recurrent miscarriage .Methods A total of 1 016 pregnant women of physical examination and normal thyroid function in the obstetric and gynecologic clinic of our hospital from March 2012 to May 2014 were selected as the research subjects .Among them ,90 cases of abortion were screened out and di‐vided into the primary abortion group(60 cases) and the recurrent abortion group(30 cases) .90 healthy childbearing age women of physical examination were selected as the control group .The positive TPOAb cases were performed statistics and compared among various groups ,the ratio was calculated;the TPOAb level was recorded in each group .At the same time the correlation between TPOAb with recurrent abortion was analyzed .Results The TPOAb positive rate in the recurrent abortion group was 46 .67% , which was significantly higher than 25 .00% in the primary abortion group and 4 .44% in the control group;at the same time the TPOAb positive rate of primary abortion group was also significantly higher than that of the control group ,the difference had sta‐tistical significance (P<0 .05) .The TPOAb concentration level in the recurrent abortion group was significantly higher than that in the primary abortion group and the control group;the TPOAb concentration level in the primary abortion group was also signifi‐cantly higher than that in the control group ,the differences were statistically significant (P< 0 .05) .In the follow‐up of adverse pregnancy occurrence with recurrent abortion as the adverse pregnancy event ,and according to the method of Spearman correlation analysis ,with the increase of TPOAb level ,the occurrence rate of recurrent miscarriage was higher ,which showed the positive cor‐relation(r=0 .764 ,P=0 .000) .Conclusion Monitoring the patient′s TPOAb level can better show the symptoms of recurrent abor‐tion .关键词
甲状腺/自身抗体/复发性流产/相关性分析Key words
thyroid gland/autoantibodies/recurrent abortion/correlation analysis分类
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纪邦群,杨玉林,郑丽波,吴世木,郭玲,刘成华,王常梅,黄蓓蓓..甲状腺自身抗体与复发性流产的相关性分析[J].重庆医学,2015,(14):1934-1935,1938,3.
