重庆医学Issue(15)：2037-2039,3.DOI:10.3969/j.issn.1671-8348.2015.15.007
犬重度心肌挫伤动物模型的建立及其应用价值
Animal model construction of dog severe myocardial contusion and its application value
张为民 1赵兴吉 1杜文华 2熊秀勤2
作者信息
- 1. 重庆市急救医疗中心胸心外科 400014
- 2. 第三军医大学大坪医院野战外科研究所超声诊断科，重庆400042
- 折叠
摘要
Abstract
Objective To establish an animal model of dog severe myocardial contusion (MC) .Methods 12 dogs with the body weight of (11 .36 ± 1 .50)kg were selected .The BIM‐Ⅱ type biological impact machine was adopted to directly impact the bare area of the left chest by the driving pressure of 800 kPa ,the impact area was 16 .61 cm2 and the chest wall was inward compressed within 4-6 cm ,the severe myocardial contusion model was established .The pathological examination was taken at 8 h after injury and grading was performed according to the Abbreviated Injury Scale (AIS ,update in 2005) .Results The scattered large area bleeding spots appeared in the epicardium and endocardium of wound area .No obvious abnormality was found in the non - wound area .The pathological examination was performed based on the coronal plane of the left ventricular cross section .The percentage of the section 8 h necrosis area to the total area was (39 .78 ± 9 .07)% .Conclusion The established dog severe myocardial contusion model is stable and reproducible ,which can accurately simulate the temporary MC mode .关键词
心肌挫伤/出血/撞击伤Key words
myocardial contusion/hemorrhage/impact injury引用本文复制引用
张为民,赵兴吉,杜文华,熊秀勤..犬重度心肌挫伤动物模型的建立及其应用价值[J].重庆医学,2015,(15):2037-2039,3.
