重庆医学Issue(15)：2045-2047,3.DOI:10.3969/j.issn.1671-8348.2015.15.010
TCT 联合DNA 定量分析在宫颈病变筛查中的临床应用
Clinical application of liquid-based cytology combined with DNA quantitative analysis in cervical lesions screening
摘要
Abstract
Objective To investigate the application value of the liquid‐based cytology test (TCT) and the DNA quantitative analysis in cervical lesions screening .Methods 2 883 cases of TCT ,1 742 cases of DNA quantitative analysis and 333 cases of TCT combined with the DNA quantitative analysis were performed the retrospective analysis for investigating their clinical significance in diagnosing the cervical lesions .Results The positive coincidence rates of TCT ,DNA quantitative analysis and their combined detec‐tion were 43 .86% ,68 .04% and 81 .16% respectively .There was statistically significant difference in the positive coincidence rates for diagnosing CIN Ⅰand above between TCT and the DNA quantitative analysis (P<0 .01);the positive coincidence rates of the combined detection had statistical difference compared with TCT and the DNA quantitative analysis (P<0 .01) .The sensitivity and the specificity of TCT for discovering the cervical lesions were 69 .44% and 92 .42% respectively ;which of the DNA quantitative a‐nalysis were 85 .71% and 87 .89% respectively ;while which of combined detection were 96 .55% and 95 .89% respectively .Conclu‐sion The DNA quantitative analysis and TCT have the higher clinical diagnostic value in the cervical lesion screening .Their com‐bined detection can more effectively increase the detection rate of cervical lesions .关键词
宫颈疾病/液基细胞学/DNA定量分析/组织病理学Key words
uterine cervical diseases/liquid-based cytology/DNA quantitative analysis/histopathology分类
医药卫生引用本文复制引用
李敏,张春梅,周仕娴,向德兵,孙贵银,李华,张朝军..TCT 联合DNA 定量分析在宫颈病变筛查中的临床应用[J].重庆医学,2015,(15):2045-2047,3.基金项目
卫生部医药卫生科技发展研究中心项目（W2011GJ25）；重庆市江津区科委项目（Y12012022）。 （）
