重庆医学Issue(16)：2222-2224,3.DOI:10.3969/j.issn.1671-8348.2015.16.022
S100B与颈动脉粥样硬化斑块稳定性关系的研究
The relationship study betweent S100B protein and stability of carotid artery arteriosclerosis
杨百元 1徐芙蓉1
作者信息
- 1. 成都市第七人民医院神经内科，成都610021
- 折叠
摘要
Abstract
Objective To investigate the correlation between S100B protein and the stability of carotid artery arteriosclero‐sis .Methods A total of 200 patients with carotid artery arteriosclerosis(CAS) were assigned as study group ,and then subdivided into stable plaques (SP)group and instable plaques (IP)group ,and 198 whoes age and gender well matched unrelated healthy sub‐jects were enrolled as control group .The levels of S100B and hs‐CRP of the 3 groups were measured by ELESA .All the diagnosis were confirmed by color Doppler and B‐ultrasound .Results The level of serum S100B was significantly higher in IP group than that of SP group and control group(P<0 .01) .There was no statistical significance between IP and SP group in the level of serum S100B(P=0 .07) .The level of hs‐CRP was significantly higher in IP group than that of SP group and control group(P<0 .01) . There was no statistical significance between IP and SP group in the level of serum hs‐CRP(P=0 .59) .Conclusion The increase of serum level of S100B in the IP CAS patients shows that S100B may take part in the pathogenic mechanism of CAS ,and regulating of S100B may become the potential therapeutic targets for CAS .关键词
S100B蛋白/超敏C反应蛋白/颈动脉粥样硬化Key words
S100B/c-reactive protein/carotid artery disease分类
医药卫生引用本文复制引用
杨百元,徐芙蓉..S100B与颈动脉粥样硬化斑块稳定性关系的研究[J].重庆医学,2015,(16):2222-2224,3.
