重庆医学Issue(18)：2454-2456,2460,4.DOI:10.3969/j.issn.1671-8348.2015.18.003
实验性大鼠轻型和重型急性胰腺炎的病理形态特点
Pathological morphological characteristics of experimental rats with acute light and heavy pancreatitis
摘要
Abstract
Objective The aim of this study is to demonstrate the pathological characteristics about two types of pancreati‐tis ,providing new thinking about the mechanism of severe acute pancreatitis .Methods Thirty male Sprague‐Dawley rats were ran‐domly divided into three equal groups :sham‐operated (SO ,n=10) group ,mild acute pancreatitis (MAP ,n=10)) group and severe acute pancreatitis (SAP ,n=10) group ,all the rats were killed after 12 h of building model .Under the microscope ,we detected the pathological changes of pancreas ,liver ,lung and small intestine .The ultrastructure of pancreas ,liver ,lung and small intestine tissue were observed by transmission electron microscope .Results In SAP group ,congestion ,edema ,inflammatory cell infiltration ,lea‐king of blood componedts ,vascular endothelial injury and thrombosis of microcirculation were obviously observed .There is no ap‐parent pathological changes in the MAP group except the edema of pancreas .Conclusion Hemorrhage and necrosis are the main pathological characteristics in SAP rats ,has essential difference with MAP .These pathological characteristics provides us a new thinking for further study about the mechanism of SAP .关键词
胰腺炎/病理学 ,临床/显微镜检查 ,电子透射Key words
pancreatitis/pathological ,clinical/micoscopy ,electron/scanning transmission分类
医药卫生引用本文复制引用
褚薇薇,闫爱丽,聂蕾,何新盈,周伊,李晟,王善伟..实验性大鼠轻型和重型急性胰腺炎的病理形态特点[J].重庆医学,2015,(18):2454-2456,2460,4.基金项目
国家自然科学基金资助项目（30772745）；陕西省教育厅资助项目（2013JK0758）。 （）
