重庆医学Issue(18)：2506-2508,3.DOI:10.3969/j.issn.1671-8348.2015.18.021
血 NGAL、CysC检测对外科重症急性肾损伤患者的早期诊断价值
Early diagnosis value of plasma NGAL,CysC on detection of surgical critical illness patients with AKI
摘要
Abstract
Objective To assess and compare the roles of plasma concentrations of neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C for early diagnosis and treatment of septic acute kidney injury (AKI) in adult Surgical critically ill patient . Methods One hundred patients were divided into two groups ,the group of 63 cases of AKI and AKI group of 37 cases ,plasma NGAL and Cystatin C level of the 2 groups were determined by the method of enzyme‐linked immunosorbent (ELISA) ,latex en‐hanced immune turbidimetry (PETIA) respectively on arrival in the surgical intensive care unit(SICU) (T0 ) and 24 h after arrival in SICU(T1 ) .Results Compared with patients in non AKI group ,both plasma NGAL and Cystatin C level of patients in AKI group on T0 and T1 increased significantly ,the difference between the two groups had significant statistical difference (P<0 .01);Although ,plasma NGAL on T1 performed less well (AUC=0 .69) ,with a threshold value of 92 ng/mL(70 .3% sensitivity ,57%specificity) .Plasma NGAL showed significant discrimination for AKI diagnosis (AUC=0 .85) with a threshold value of 65 .95 ng/mL(81 .8% sensitivity ,76 .2% specificity) on T0 .Both plasma Cystatin C on T0 and T1 worked well for the diagnosis of AKI (AUC=0 .90 ,0 .88 ,thresholds 1 .49 and 1 .47 mg/L ,respectively) ,with diagnostic sensitivity of 89 .2% ,82 .5% respectively ,speci‐ficity of 83 .8% ,76 .2% respectively .Conclusion Plasma NGAL and Cystatin C are useful markers in predicting AKI in surgical critically ill patients ,the early diagnosis value of plasma Cystatin C for AKI is better than plasma NGAL on arrival in the surgical intensive care unit .关键词
肾疾病/脂笼蛋白质类/半胱氨酸蛋白酶抑制剂/生物学标记/预测/SICUKey words
kidney disease/lipocalins/cysteine proteinase inhibitors/biological makers/forecasting/surgical intensive care u-nits分类
医药卫生引用本文复制引用
刘新龙,岳锦熙,苏美仙..血 NGAL、CysC检测对外科重症急性肾损伤患者的早期诊断价值[J].重庆医学,2015,(18):2506-2508,3.基金项目
云南省教育厅科学研究基金项目资助（2013Y293）。 （）
