重庆医学Issue(19)：2618-2620,3.DOI:10.3969/j.issn.1671-8348.2015.19.009
99Tcm-MNLS 与99Tcm-HL91乏氧显像评估肿瘤放疗后乏氧状态的对比实验研究
Comparison between 99 Tcm-MNLS and 99 Tcm-HL91 in assessing the hypoxia of the tumor after radiotherapy
胡玉敬 1边艳珠 1张文艳 1吴大勇 1魏强1
作者信息
- 1. 河北省人民医院核医学科，石家庄050051
- 折叠
摘要
Abstract
Objective To compare the imaging of 99 Tcm‐MNLS and 99 Tcm‐HL91 for the hypoxic assessment in the tumor af‐ter radiotherapy .Methods Twenty four Kunming mice models bearing H22 liver cancer xenografts which tumor were treated ra‐diotherapy for 25 Gy were divided into 99 Tcm‐MNLS instant group ,99 Tcm‐MNLS 48 h group ,99 Tcm‐HL91 instant group ,99 Tcm‐HL91 48 h group and injected the matching 99 Tcm‐MNLS or 99 Tcm‐HL91 to image .The technique of ROI was adopted to calculated the T/NT on the image .Immunohistochemical stain methods were used to evaluate the level of HIF‐1αabout tumors after imaging . Two sample t test was performed .Results The T/NT and the HIF‐1α level about instant (3 .36 ± 0 .20 ,88 .55% ± 0 .83% )were higher than and 48 h (2 .25 ± 0 .43 ,22 .75% ± 3 .35% )in 99 Tcm‐MNLS group(P<0 .05) ,then in 99 Tcm‐HL91 group the T/NT and the HIF‐1αlevel about instant (3 .23 ± 0 .90 ,90 .55% ± 2 .61% )were higher than 48 h (2 .79 ± 0 .85 ,25 .88% ± 3 .76% )(P<0 .05) .The difference of T/NT ,HIF‐1αlevel about instant in 99 Tcm‐MNLS group and 99 Tcm‐HL91 group were no significant(P>0 .05)and the same to the T/NT ,HIF‐1αlevel about 48h in 99 Tcm‐MNLS group and 99 Tcm‐HL91 group(P>0 .05) .Conclusion 99 Tcm‐MNLS hypoxia imaging could provide the change of hypoxia comparable to 99 Tcm‐HL91 ,and the two radiopharmaceutical could both show high accuracy rate in evaluating the hypoxia in the tumor .关键词
甲硝唑/锝/缺氧/肝肿瘤/小鼠/放射性核素显像/乏氧诱导因子-1αKey words
metronidazole/technetium/anoxia/liver neoplasms/mice/radionuclide imaging/HIF-1α分类
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胡玉敬,边艳珠,张文艳,吴大勇,魏强..99Tcm-MNLS 与99Tcm-HL91乏氧显像评估肿瘤放疗后乏氧状态的对比实验研究[J].重庆医学,2015,(19):2618-2620,3.
