电子学报Issue(1)：120-128,9.DOI:10.3969/j.issn.0372-2112.2015.01.019
面向短 QT 综合征的电生理建模与仿真研究进展
Research Advance on the Electrophysiological Modeling and Simulation of Short QT Syndrome
摘要
Abstract
Multi-physical scale modeling for simulating the electrophysiological dynamics of the heart is rapidly evolving and has made significant progress in the last decade .In this paper ,we briefly review the current development of cardiac modeling field with a particular focus on the modeling of short QT (SQT )syndrome arising from gene mutations in cardiac potassium channels . Firstly ,we introduce Denis Noble’s definition on multi-physical scale modeling of cardiac systems at sub-cellular ,cellular ,tissue and whole organ levels .Secondly ,we describe quantities that have been used to characterize the functional impacts of SQT gene muta-tions on the electrical activity of cardiac systems at cellular ,tissue and whole organ levels .Then we review up-to-date research re-sults on quantifying the functional impacts of three SQT gene mutations associated with potassium channels on the genesis of cardiac arrhythmia that underlie cardiac sudden death .Finally we outline possible research and application prospects of the electrophysi-ological modeling and simulation of SQT syndrome in the future .关键词
虚拟心脏/计算心脏学/建模与仿真/短QT综合征/基因突变Key words
virtual heart/computational cardiology/modeling and simulation/short QT syndrome/gene mutation分类
信息技术与安全科学引用本文复制引用
罗存金,王宽全,袁永峰,吕伟刚,Henggui Zhang..面向短 QT 综合征的电生理建模与仿真研究进展[J].电子学报,2015,(1):120-128,9.基金项目
国家自然科学基金（No ．61179009，No ．61173086）；国家自然科学青年基金 （）
