吉林医药学院学报Issue(1)：1-3,3.
齐墩果酸对CCl 4诱导小鼠急性肝损伤保护作用的实验研究
The protective effects of oleanolic acid against carbon tetrachloride-induced acute liver injury in mice
郗艳丽 1吴启坤 1冯威 1张洋婷 1宋春梅 1马洪波 1王舒然1
作者信息
- 1. 吉林医药学院公共卫生学院，吉林 吉林 132013
- 折叠
摘要
Abstract
Objective To study the protective effects of oleanolic acid against carbon tetrachloride-induced acute liv-er injury in micee .Methods Thirty male mice were randomly divided into normal group ,model group and oleanolic acid group .Oleanolic acid group was pretreated with oleanolic acid and soybean oil mixture solution by intragastric ad -ministration at the dosage of 300 mg/kg for 2 days;model and normal groups were pretreated with the same volume of soybean oil .On the last day of intragastric administration ,model and oleanolic acid groups were subcutaneous injected with 3 mL/kg carbon tetrachloride ,and normal group was subcutaneous injected with the same volume of physiological saline .Twenty-four hours after subcutaneous injection ,the mice were sacrificed and livers were removed .The contents of SOD and MDA from liver homogenate serum were determined ,and the organ coefficient and pathological changes of liver were also measured .Results Oleanolic acid significantly increased the low level of SOD and decreased the high level of MDA-induced by carbon tetrachloride .Compared with the model group ,the organ coefficient and patho-logical damage of liver in oleanolic acid group was slightly decreased .Conclusion Oleanolic acid has protective effects against acute liver injuryinduced by carbon tetrachloride .关键词
齐墩果酸/急性肝损伤/保护作用Key words
oleanolic acid/acute liver injury/protective effects分类
医药卫生引用本文复制引用
郗艳丽,吴启坤,冯威,张洋婷,宋春梅,马洪波,王舒然..齐墩果酸对CCl 4诱导小鼠急性肝损伤保护作用的实验研究[J].吉林医药学院学报,2015,(1):1-3,3.
