动物医学进展Issue(6)：103-106,4.
戊型肝炎病毒感染模型研究进展
Progress on Infection Models of Hepatitis E virus
摘要
Abstract
Hepatitis E is an important zoonotic disease caused by hepatitis E virus (HEV)that has high di-versity and many hosts.Due to difficult culture in vitro ,the development of HEV infection model for in-depth study is essential.the establish of an ideal infection model definitely will benefit the study on mecha-nism of replication,pathogenicity and cross-species infection of HEV.Animal models like nonhuman pri-mates,pigs,rabbits and cell culture system are possibly used as infection models.Nonhuman primates are practical models but limitation on cost,availability,manipulate and housing.Pigs and rabbits are relative-ly low cost,easy to manipulate,but only susceptible to genotype 3 and/or type 4.Among these animal model,Mongolian gerbil is the most practical at present.Cell culture systems have now become available, human hepatocellular carcinoma cell line PLC/PRF/5 and lung cancer cell A549 are the most effective cul-ture system.关键词
戊型肝炎病毒/感染模型/宿主Key words
Hepatitis E virus/infection model/host分类
农业科技引用本文复制引用
李文贵,段新慧,张佳,严红亚..戊型肝炎病毒感染模型研究进展[J].动物医学进展,2014,(6):103-106,4.基金项目
国家自然科学基金项目 （）
