动物医学进展Issue(6)：114-116,3.
组织蛋白酶K在骨吸收中的作用研究进展
Progress on Action of Cathepsin K in Bone Resorption
摘要
Abstract
Cathepsin K is one of lysosomal cysteine proteases,belongs to the papaya protease superfamily,highly expressed in the process of bone resorption mediated by osteoclasts and degrade matrix proteins in bone tissue ef-fectively,plays a significant role in the process on bone resorption.Study of the importance of cathepsin k in bone resorption opened up a new approach to metabolic bone disease treatment.In this mini-review,we mainly focused on the structure and function of cathepsin K and the interaction with osteoclast,the regulation mechanisms of ex-pression levels in the process of bone resorption.关键词
组织蛋白酶 K/破骨细胞/骨吸收Key words
cathepsin K/osteoclast/bone resorption分类
农业科技引用本文复制引用
王东,顾建红,刘宗平..组织蛋白酶K在骨吸收中的作用研究进展[J].动物医学进展,2014,(6):114-116,3.基金项目
国家自然科学基金项目（31372495，31302154）；江苏省高校自然科学研究项目（13KJB230002）；国家自然科学青年基金项目（31302154）；高校博士点基金（新教师类） （）
