动物医学进展Issue(8)：54-58,5.
基于生理药动学模型计算氟甲喹在家兔体内的药动学参数
Calculation of Pharmacokinetics Parameters of Flumequine in Rabbits Using a Physiologically Based Pharmacokinetics Model
摘要
Abstract
In order to illuminate the absorption ,distribution ,metabolism and excretion of flumequine in rabbits ,and to determine flumequine's optimal dosing regimen ,the physiological and anatomical parame-ters in rabbits were collected from the previous studies .Then a blood-flow limited physiologically based pharmacokinetics (PBPK) model including ten compartments was developed .The modules representing o-ral exposure ,gastrointestinal absorption ,and hepatic metabolism were incorporated into the present model to predict flumequine concentrations in tissues and plasma after one single oral dose at 15 mg/kg in rab-bits .The predicted plasma concentrations were subjected to compartmental and non-compartmental analy-ses to obtain the pharmacokinetics parameters of flumequine in rabbits .The results presented here showed that flumequine was rapidly absorbed ,extensively distrubuted into all tissues ,and eliminated rapidly from rabbits after oral administration .关键词
氟甲喹/生理药动学模型/药动学参数/家兔Key words
flumequine/physiologically based pharmacokinetics model/pharmacokinetics parameter/rabbit分类
农业科技引用本文复制引用
杨帆,杨芳,赵振升,周变华,郝雪琴..基于生理药动学模型计算氟甲喹在家兔体内的药动学参数[J].动物医学进展,2014,(8):54-58,5.基金项目
河南科技大学博士启动基金项目 （）
