动物医学进展Issue(11)：44-47,48,5.
金属阳离子影响卵磷脂-胆固醇脂质体结构稳定性的形态学分析
Morphological Analysis of Effect of Metal Cations on Structural Stability of Phosphatidylcholine/Cholesterol Liposomes
摘要
Abstract
This article showed primary study and analyses on the impacts done by the metal cations to the stability of liposomes which are made of cholesterol and lecithin.Using images given by atomic force mi-croscope,the interaction mechanism in nanoscale was investigated and conducted by methods combining basic principles of thermodynamics,electrostatics and colloid science.The study illustrated that the pro-portion of cholesterol significantly influenced the fluidity and stability of the lipid membrane.Meanwhile, it also indicated that the cations could influence these liposomes both on the ability of assembling them-selves and on the thermodynamic stability by interactions with polar heads of the phospholipid molecules.关键词
脂质体/阳离子/结构稳定性/原子力显微镜Key words
liposome/cation/structural stability/atomic force microscopy分类
农业科技引用本文复制引用
张诗音,肖启,寇贝贝,朱杰,王国栋..金属阳离子影响卵磷脂-胆固醇脂质体结构稳定性的形态学分析[J].动物医学进展,2014,(11):44-47,48,5.基金项目
国家自然科学基金项目（11202170）；西北农林科技大学大型仪器设备新功能开发项目（dysb130105）；西北农林科技大学大学生创新训练计划项目 （）
