动物医学进展Issue(12)：73-76,4.
精氨酸对孕鼠子宫 NO 和微血管的影响
Effects of Arginine on NO and Microvessels of Uteroplacenta in Mice
摘要
Abstract
The objective is to investigate the effects of arginine on fetal microvessels in mice,to illuminate the mechanismts of the intrauterine growth retardation (IUGR).120 female mice were randomly divided into six groups according to arginine(Arg)levels supplemented in diets.Arg supplements in groups con-trol,A,B,C,D,E were 0,2.5,5,7.5,10,15 mL/kg,respectively.Mice consumed the diets and water free-ly.10 mice from each group were randomlyselected and killed,detecting IUGR,microvessel density of u-terus and placenta,distribution NOS activity and NO content on gestational 16th day.Compared with the control mice,the dietary supplementation with B to E Arg decreased the IUGR rates.The uterine NOS ac-tivity,placental NOS activity and placental tissue NO content of pregnancy mice in B,C,D,E were signif-icantly increased (P <0.01),pathological changes wasn′t found in the experiment.The microvessel densi-ties of uterus and placenta in group B were increased by 16.30% and 10.58% respectively compared with control,but not significant (P >0.05).The results indicated that Arg can improve uteroplacental circula-tion and maternal-fetal nutritive substance supplement,thus contributing to relieve IUGR.关键词
精氨酸/宫内生长迟缓/微血管密度/一氧化氮/小鼠Key words
arginine/intrauterine growth retardation/microvessel density/nitric oxide/mouse分类
农业科技引用本文复制引用
欧德渊,万洁妤,李秀富,李诗举,艾淼,施云刚..精氨酸对孕鼠子宫 NO 和微血管的影响[J].动物医学进展,2014,(12):73-76,4.基金项目
贵州省自然科学基金项目（黔科合 J 字（2012）2146号） （）
