动物医学进展Issue(1)：96-100,101,6.
Toll 样受体信号转导的负调控机制研究进展
Progress on Negative Regulatory Mechanism of Toll-like Receptor Signal Transduction
摘要
Abstract
This paper summarized the negative regulation of TLRs mediated inflammatory response path‐way .The study found that many negative regulatory proteins negatively regulate TLRs signal pathway by different mechanisms (degradation and antagonist ) targeting key signaling molecules ,interfere with con‐nection complex formation in signal transduction pathway .ubiquitination and degradation of adaptor pro‐tein in signaling pathway ,transcription regulation ,inhibit ,and maintain immune homeostasis .The paper reviewed the transduction pathway of TLRs signal and its negative regulatory mechanism .关键词
Toll样受体/免疫/负向调控/信号转导Key words
Toll-like receptor/immunity/negative regulation/signal transduction分类
农业科技引用本文复制引用
高明,敖越,栾新红..Toll 样受体信号转导的负调控机制研究进展[J].动物医学进展,2015,(1):96-100,101,6.基金项目
国家自然科学基金面上项目（31172286）；辽宁豁眼鹅产蛋性能主效基因筛选及新基因克隆项目 （）
