动物医学进展Issue(4)：96-99,100,5.
沙门菌免疫逃逸机制及其应用研究进展
Progress on Application of Immune Evasion Mechanisms by Salmonella
摘要
Abstract
Hosts recognize pathogen-associated molecular patterns (PAMPs)by pattern recognition recep-tors (PRRs)to activate the innate and adaptive immune response.However,Salmonella has evolved corre-sponding evasion mechanisms to escape host immune defense.One of evasion mechanisms by Salmonella is to interfere with Toll like receptor-nuclear factor κB (TLRs-NF-κB) signaling,including modifying PAMPs,secreting TIR mimics and inhibiting the degradation of IκB.The other evasion mechanisms media-ted by dendritic cells (DCs)include impairing antigen presentation by DCs,reducing FliC production,mi-grating attached to DCs and forming SCV.To exploit immune evasion mechanisms by Salmonella will pro-vide new idea for the design of effective vaccines and drugs.关键词
沙门菌/Toll样受体-核转录因子κB/树突状细胞/免疫逃逸/应用Key words
Salmonella/Toll like receptor-nuclear factorκB,NF-κB/dendritic cell/immune evasion/appli-cation分类
农业科技引用本文复制引用
熊丹,宋丽,胡茂志,潘志明,焦新安..沙门菌免疫逃逸机制及其应用研究进展[J].动物医学进展,2015,(4):96-99,100,5.基金项目
国家自然科学基金项目（31320103907，31372414）；公益性行业（农业）科研专项（201403054）；教育部新世纪优秀人才支持计划项目（NCET-12-0745）；2012年度高校“青蓝工程”中青年学术带头人培养对象项目、江苏高校优势学科建设工程项目 （）
