动物营养学报Issue(3)：663-670,8.DOI:10.3969/j.issn.1006-267x.2015.03.001
甘氨酸的免疫调节作用及其分子机制
Immunomodulatory Effects of Glycine and Its Molecular Mechanism
摘要
Abstract
Glycine is a simple, non-essential amino acid, participates in the synthesis of protein and many physiologically important molecules, and it has been well characterized as an inhibitory neurotransmitter in the central nervous system. Except for the protection of glycine in experimental models of ischaemia-reperfusion in-jury, shock, transplantation, alcoholic hepatitis, hepatic fibrosis, arthritis, tumour and drug toxicity, ample evidence has been generated demonstrating that glycine has anti-inflammatory and immunomodulatory function, but the exact mechanism( s) responsible for the protective and anti-inflammatory action of glycine are still un-clear. This paper reviewed the basic characteristics, the physiological protective fuctions, anti-inflammatory and immunomodulatory effects and possible molecular mechanisms of glycine, discussed the modulation possi-bility of glycine on mastitis control of lactating ruminants, and provided promising insights into the develop-ment of glycine as a natural immunomodulatory agent in practice.关键词
甘氨酸/抗炎/甘氨酸受体Key words
glycine/anti-inflammatory/glycine receptor分类
农业科技引用本文复制引用
杜瑞平,张兴夫,高民,敖长金..甘氨酸的免疫调节作用及其分子机制[J].动物营养学报,2015,(3):663-670,8.基金项目
国家“973”重点基础研究发展计划(2011CB100803) （2011CB100803）
中科院“西部之光”人才培养项目 （）
