南方医科大学学报Issue(6)：852-856,861,6.DOI:10.3969/j.issn.1673-4254.2014.06.20
激光熔覆技术制备的纳米钽-钛合金棒结构特征及生物相容性
Structural characteristics and biocompatibility of a new Nano-Ta-Ti alloy rod fabricated by laser melting technique
摘要
Abstract
Objective To evaluate the structural characteristics and biocompatibility of a novel nano-Ta-Ti alloy rod for its potential application in internal fixation. Methods Ta coating of a Ti alloy rod with nano-Ta (tantalum) powder was performed using laser melting with symmetrical grooves repleted with nano-Ta powder along the whole length. The microstructure of the cross section of Ta-Ti alloy rod, pore diameter and components of the coating were analyzed using scanning electron microscopy. The influence of this nano-Ta-Ti alloy on proliferation and differentiation of MC3T3-E1 cells was evaluated by MTT cytotoxicity test and ALP activity test. Results Under scanning electron microscope, the Ta-coating surface presented with a gross porous (200-300μm) structure with dense fusion between Ta particles, and no new element was produced after laser melting. Biocompatibility evaluation showed that Ti alloys with and without Ta coating both promoted the proliferation of MC3T3-E1 cells, but the coated alloy showed better performance and obviously promoted the differentiation of the osteoblasts. Conclusion Alloying between Ta and Ti can be accomplished successfully by laser melting technique, and the alloy obtained has ideal surface structure and good biocompatibility.关键词
纳米钽/多孔/激光熔覆/微区组织结构/生物相容性Key words
nano-Ta/porous/laser melting/microstructure/biocompatibility引用本文复制引用
邹琳,江建明,杨勇,陈长军,瞿东滨..激光熔覆技术制备的纳米钽-钛合金棒结构特征及生物相容性[J].南方医科大学学报,2014,(6):852-856,861,6.基金项目
国家自然科学基金（81272022）；南方医科大学南方医院2010年度院长基金（2010A002）@@@@Supported by National Natural Science Foundation of China(81272022) （81272022）
