南方医科大学学报Issue(12)：1814-1817,1821,5.DOI:10.3969/j.issn.1673-4254.2014.12.22
血清VEGF-C、VEGF-D及VEGFR-3联合TSH检测在甲状腺乳头状癌诊断中的价值
Value of VEGF-C, VEGF-D and VEGFR-3 levels combined with serum TSH in diagnosis of papillary thyroid carcinoma
摘要
Abstract
Objective To investigate serum vascular endothelial growth factor-C (VEGF-C), VEGF-D and VEGFR-3 levels in patients with papillary thyroid carcinoma (PTC) and analyze their relation with the clinicopathological and thyroid function of the patients. Methods Serum samples and the data of thyroid function were collected from 55 patients with PTC and 24 with benign thyroid tumor (BT). ELISA was used to detect VEGF-C/D and VEGFR-3 concentration in the serum samples and their relation with the thyroid function was analyzed. Results The VEGF-C and VEGFR-3 levels were significantly higher in PTC group than in BT group (P<0.05), but VEGF-D level was comparable between them (P>0.05). In PTC patients, the elevation of serum VEGF-C and VEGFR-3 levels was associated with an advanced clinical stage (III-IV), elevated thyroid-stimulating hormone (TSH) level, an age over 45 years, and a tumor diameter exceeding 2 cm (P<0.05 or P<0.01). Patients with lymph node metastasis had significantly higher VEGF-C level but lower VEGF-3 level than those without metastasis regardless of gender. Serum VEGF-D level was higher in PTC patients with lymph node metastasis (P<0.05) and elevated TSH level (P<0.01) without association with the clinical stage, tumor diameter, age, or gender. The area under ROC curve (AUC) of serum VEGF-C, VEGFR-3 and TSH was 0.803, 0.734 and 0.707 respectively (P<0.01), and that of VEGF-D was 0.556 (P>0.05);when combined, serum VEGF-C, VEGFR-3 and TSH showed an AUC of 0.862 (P<0.01). Conclusion Detecting serum VEGF-C and VEGFR-3 levels combined with TSH may enhance the early diagnosis rate of papillary thyroid carcinoma.关键词
甲状腺乳头状癌/淋巴结转移/VEGF-C/VEGF-D/VEGFR-3/TSH/酶联免疫吸附试验Key words
papillary thyroid carcinoma/lymph node metastasis/vascular endothelial growth factors/thyroid-stimulating hormone引用本文复制引用
黄静,李燕萍,薛刚,张文静,李少英,张静,吴靖芳..血清VEGF-C、VEGF-D及VEGFR-3联合TSH检测在甲状腺乳头状癌诊断中的价值[J].南方医科大学学报,2014,(12):1814-1817,1821,5.基金项目
河北省教育厅重点项目（ZD2010101）；河北省科技厅项目（12276104D-91）；河北北方学院重大项目 （）
