南方医科大学学报Issue(1)：34-39,55,7.DOI:10.3969/j.issn.1673-4254.2015.01.07
中心动脉脉压是影响大动脉僵硬度的主要因素
Central pulse pressure but not brachial blood pressure is the predominant factor affecting aortic arterial stiffness
摘要
Abstract
Objective To investigate the differences in central hemodynamic indices between hypertensive and normotensive subjects and identify the blood pressure index that the most strongly correlate with arterial stiffness and vascular damage markers. Methods A cohort of 820 hypertensive patients and 820 normotensive individuals matched for age and gender were enrolled in this study. We measured carotid-femoral and carotid-radial pulse wave velocity (PWV), aortic augmentation index (AIx) and central blood pressures using pulse wave analysis and applanation tonometry. Plasma homocysteine (HCY), high-sensitivity C-reactive protein (hsCRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were also tested in these subjects. Results In both hypertensive and normotensive subjects, the central systolic blood pressure (SBP) and pulse pressure (PP) were significantly lower than brachial SBP and PP; this PP amplification was significantly lower in the normotensives (9.85 ± 6.55 mmHg) than in the hypertensives (12.64 ± 6.69 mmHg), but the amplification ratios were comparable between the two groups. Blood pressure and age were closely related with aortic arterial stiffness. Compared with normotensive subjects, hypertensive subjects had higher carotid-femoral PWV and AIx, and showed significantly lowered PP amplification ratio with age. Central PP was more strongly related to arterial stiffness and vascular damage markers than the other pressure indices. Multivariate analyses revealed that carotid-femoral PWV and aortic AIx were strongly influenced by central PP but not by the mean blood pressure or brachial PP. Conclusion The central PP is a more direct indicator of central arterial stiffness and a better marker of vascular aging than other blood pressure variables. These findings support the use of central blood pressure as a treatment target in future trials.关键词
高血压/中心动脉压/动脉僵硬度/压力波反射Key words
hypertension/central blood pressure/arterial stiffness/pressure wave reflections引用本文复制引用
肖文凯,叶平,白永怿,骆雷鸣,吴红梅,高鹏..中心动脉脉压是影响大动脉僵硬度的主要因素[J].南方医科大学学报,2015,(1):34-39,55,7.基金项目
国家自然科学基金（81270941）Supported by National Natural Science Foundation of China (81270941) （81270941）
