南方医科大学学报Issue(2)：208-212,5.DOI:10.3969/j.issn.1673-4254.2015.02.10
弥漫大B细胞淋巴瘤化疗中后期用18F-FDG PET/CT显像预测预后是否优于化疗中期？
18F-FDG PET/CT for predicting outcomes of diffuse large B-cell lymphoma：shall it be performed in the interim versus later phase of chemotherapy?
摘要
Abstract
Objective To compare the value of 18F-FDG PET/CT performed in the interim and later phase of chemotherapy in predicting the prognosis of diffuse large B-cell lymphoma (DLBCL). Methods 18F-FDG PET/CT was performed in 71 patients with DLBCL in the interim phase of chemotherapy (3-4 cycles) and in another 71 patients in the later phase of chemotherapy (5-8 cycles). The patients were followed up for an average of 28.73 months (18-114 months) to compare the progression-free survival (PFS) and the PFS rate. Results The positive finding rate was similar between 18F-FDG PET/CT performed in the interim and the later phase (36.6%vs 33.8%,χ²=12.423, P>0.05). The PFS was much longer in patients with negative findings than in those with positive findings in both the interim (63.56 vs 19.23 months, P=0.000) and later phase groups (65.78 vs 24.32 months, P=0.000), but showed no significant difference between the negative patients (P>0.05) or between the positive patients (P>0.05) in the two groups. The PFS rate was significantly greater in patients with negative than those with positive findings in the interim group (73.3%vs 15.4%, P=0.000) and in the later phase group (74.5%vs 16.7%, P=0.000), but comparable between the negative (P>0.05) and between the positive patients (P>0.05) in the two groups. Conclusions 18F-FDG PET/CT in the interim and later phase of chemotherapy has similar value for predicting the prognosis of DLBCL, and we therefore recommend that 18F-FDG PET/CT be performed in the interim but not in the later phase.关键词
弥漫大B细胞淋巴瘤/化学疗法/发射型计算机体层摄影术/X线计算机/预测预后Key words
diffuse large B-cell lymphoma/chemotherapy/emission-computed tomography/X-ray computed/prognosis prediction引用本文复制引用
李蕙旨,吴湖炳,王全师,李洪生,周文兰,田颖,董烨..弥漫大B细胞淋巴瘤化疗中后期用18F-FDG PET/CT显像预测预后是否优于化疗中期？[J].南方医科大学学报,2015,(2):208-212,5.基金项目
国家自然科学基金 （）
