南方医科大学学报Issue(6)：922-926,5.
阻塞性睡眠呼吸暂停低通气综合征与年龄对睡眠结构的影响
Effects of obstructive sleep apnea-hypopnea syndrome and age on sleep architecture
摘要
Abstract
Objective To investigate the effects of obstructive sleep apnea-hypopnea syndrome (OSAHS) and age on sleep architecture and the therapeutic effects of continuous positive airway pressure (CPAP). Methods We retrospectively analyzed 222 subjects undergoing polysomnography (PSG) for snoring, who received CPAP under PSG on the next day following the initial PSG. The sleep architecture of the subjects in different age groups and in groups with different severities of OSAHS was analyzed before and after adjustment for apnea-hypopnea index (AHI) or age. The sleep architecture and ventilation function of the patients with OSAHS were also analyzed after CPAP. Results N3 sleep showed the strongest correlation with AHI (r=-0.361), and REM sleep and wake after sleep onset (WASO) were the most strongly correlated with age (r=-0.211 and 0.216, respectively). The 4 age groups showed significant differences in sleep efficiency (P<0.001), N1 (P=0.015), N2 (P=0.013) and REM (P=0.030) sleeps, and WASO (P=0.001) but not in AHI (P=0.185). REM sleep decreased and WASO increased with an increasing age. The sleep efficiency and architecture were still significant different after adjustment for AHI. In 4 groups with different severity of OSAHS, N1, N2 and N3 sleeps were significant different after adjustment for age (P=0.011, 0.017, 0.001). In patients with moderate or severe OSAHS, N3 sleep increased with the increase of AHI. After CPAP for OSAHS, N1 and N2 sleeps significantly decreased, and N3 and REM sleeps increased (P<0.001). Conclusions Between OSAHS and age, REM sleep and WTSO are more importantly affected by age, while OSAHS more strongly affects N3 sleep. CPAP can improve the sleep quality of patients with OSAHS.关键词
阻塞性睡眠呼吸暂停低通气综合征/年龄/睡眠结构/持续气道正压通气Key words
obstructive sleep apnea hypopnea syndrome/age/sleep architecture/continuous positive airway pressure引用本文复制引用
郭东英,彭辉,冯媛,李丹青,许婷,李涛平,廖生武..阻塞性睡眠呼吸暂停低通气综合征与年龄对睡眠结构的影响[J].南方医科大学学报,2015,(6):922-926,5.基金项目
十二五国家科技支撑计划（2012BAI05B03）；广东省科技计划项目（2012B031800467，2011B090400378） Supported by National "Twelfth Five Year Plan" for Sci & Tech Research (2012BAI05B03) （2012BAI05B03）
