分析测试学报Issue(10)：1173-1177,5.DOI:10.3969/j.issn.1004-4957.2014.10.013
多虑平类化合物的核磁共振图谱特征分析
Analysis on NMR Spectral Characteristics of Doxepin Compounds
摘要
Abstract
ln this work,NMR spectral characteristics of doxepin compounds were investigated with various experimental conditions, taking 11-( 3-dimethylaminopropylidene )-6, 11-dihydro-dibenzo [ b,e]oxepine-2- carbaldehyde( DP)as the testing sample. The conformation exchange of DP was confirmed. lt was proved that the NMR spectral characteristics would depend on the experimental conditions,and the temperature would greatly affect the characteristics of the signals. Under the room temperature,the phenomena of signal broadening and missing were observed. As a result,the NMR signal assignment could not be accomplished. These phenomena could be improved with in-crease of temperature. The abnormal phenomena were effectively inhibited at 80 ℃. Finally,the complete assignment was presented and configuration was confirmed.关键词
多虑平类化合物/图谱解析/核磁共振/构象交换Key words
doxepin compounds/analysis for spectra/NMR/conformation exchange分类
化学化工引用本文复制引用
韩娇,何清,李茵萍,孙瑞琪,杜树山,邓志威,耿珠峰..多虑平类化合物的核磁共振图谱特征分析[J].分析测试学报,2014,(10):1173-1177,5.基金项目
国家自然科学基金资助项目 （）
