分析化学Issue(8)：1099-1103,5.DOI:10.11895/j.issn.0253-3820.140062
因子分析法在质谱成像数据分析中的应用
Application of Factor Analysis in Imaging Mass Spectrometric Data Analysis
摘要
Abstract
The factor analysis method applied in imaging mass spectrometry data analysis was studied. The imaging mass spectrometric data were obtained by air flow-assisted ionization imaging mass spectrometry method. The sample contained some symbols which were drawn on slides using three different inks ( red, blue, black) . The imaging data analyzed by factor analysis method were divided into the background, black, blue and red factor. The results showed that the scores of m/z=443. 2, 478. 4, 322. 2(344. 2) in red, blue, black factor respectively were much larger than others. Therefore, they were markers of three inks. The results accorded with actual condition well and proved that the application of factor analysis in imaging mass spectrometric data analysis was feasible. The data analysis results of factor analysis and principal component analysis were compared. The results showed that the target sample markers could be extracted by factor analysis simply and quantitatively. It was of great potential in biomarker extraction, diseases diagnose and pharmacological analysis.关键词
因子分析/质谱成像/空气动力辅助离子源/多元统计Key words
Factor analysis/Imaging mass spectrometry/Air flow-assisted ionization/Multiple statistical analysis引用本文复制引用
陈一,唐飞,李铁刚,贺玖明,再帕尔·阿不力孜,刘力涛,王晓浩..因子分析法在质谱成像数据分析中的应用[J].分析化学,2014,(8):1099-1103,5.基金项目
本文系国家重大科学仪器设备开发专项(Nos.2011YQ17006702,2011YQ14015010)、国家自然科学基金(No.81102413)、深圳市科技研发资金基础研究计划(No. JC201005280634A)项目资助@@@@This work was supported by the National Instrumentation Programmme (Nos.2011YQ17006702,2011YQ14015010), the National Natural Science Foundation of China (No.81102413), and the Fundamental Research Program of Shenzhen (No. JC201005280634A) （Nos.2011YQ17006702,2011YQ14015010）
