分析化学Issue(9)：1359-1363,5.DOI:10.11895/j.issn.0253-3820.140140
硫酸改性聚（甲基丙烯酸缩水甘油酯-乙二醇二甲基丙烯酸酯）固相微萃取涂层-高效液相色谱检测水中4种药品及个人护理用品
Sulfuric Acid Modified Poly (GMA-EGDMA) Coating for Solid Phase Microextraction Coupled with High Performance Liquid Chromatography and Its Application to Determination of Four Pharmaceuticals and Personal Care Products in Water
摘要
Abstract
A poly( GMA-EGDMA) coated SPME fiber was prepared using an in-situ polymerization by direct bonding to the surface of a polydopamine-modified stainless steel wire. Then the fiber was modified by sulfuric acid. A novel solid phase microextraction coating coupled to high performance liquid chromatography ( HPLC) method based on the as-prepared fiber was developed for the determination of four pharmaceuticals and personal care products ( PPCPs) in water samples. The influences of extraction parameters, including pH, extraction time, extraction temperature and salt addition were investigated. 3 mL water sample was extracted by the as-prepared fiber for 60 min at 30 ℃, and then desorbed with mobile phase for 30 min, respectively. Desorption solution was analyzed by HPLC-DAD ( diode array detection ) . The results indicated that the extraction yield of the fiber was good for four PPCPs. The linear correlation coefficients were>0. 997 with the linear range of 2-200 μg/L. The limits of detection (S/N=3) were 0. 5-5 μg/L with RSD (n=5) of 4. 1%-11. 9%. The recoveries of four PPCPs at spiked level of 20, 50, 100 μg/L were within the range of 70. 6%-105. 5%. The results showed that this method was easy, green, accurate and precise, and could be used to assay the four PPCPs in real water samples.关键词
药品及个人护理用品/固相微萃取/硫酸改性聚(甲基丙烯酸缩水甘油酯-乙二醇二甲基丙烯酸酯)/高效液相色谱Key words
Personal care products/Solid phase microextraction/Sulfuric acid modification poly ( glycidyl methacrylate-ethyleneglycoldimethacrylate)/High performance liquid chromatography引用本文复制引用
彭英,庄园,何欢,孙成,杨绍贵..硫酸改性聚（甲基丙烯酸缩水甘油酯-乙二醇二甲基丙烯酸酯）固相微萃取涂层-高效液相色谱检测水中4种药品及个人护理用品[J].分析化学,2014,(9):1359-1363,5.基金项目
国家自然科学基金(No.21207061)和江苏省环境监测科研基金(No.1303)资助项目 （No.21207061）
