法医学杂志Issue(3)：219-226,8.DOI:10.3969/j.issn.1004-5619.2015.03.012
代谢组学在法医毒理学的应用进展
Development and Application of Metabonomics in Forensic Toxicology
摘要
Abstract
Metabonom ics is an im portant branch of system biology follow ing the developm ent of ge-nom ics, transcriptom ics and proteom ics. It can perform high-throughput detection and data processing with multiple param eters, potentially enabling the identification and quantification of all sm all m etabolites in a biological system . It can be used to provide com prehensive inform ation on the toxicity effects, toxi-cological mechanisms and biom arkers, sensitively finding the unusual m etabolic changes caused by poi-son. This article mainly review s application of m etabonom ics in toxicological studies of abused drugs, pesticides, poisonous plants and poisonous anim als, and also illustrates the new direction of forensic toxi-cology research.关键词
法医毒理学/代谢组学/综述文献类型Key words
forensic toxicology/m etabonom ics/review [publication type分类
社会科学引用本文复制引用
严慧,沈敏..代谢组学在法医毒理学的应用进展[J].法医学杂志,2015,(3):219-226,8.基金项目
国家自然科学基金青年科学基金资助项目（81302614）；上海市自然科学基金资助项目（13ZR1443000）；上海市法医学重点实验室资助项目 （）
