高等学校化学学报Issue(7)：1509-1514,6.DOI:10.7503/cjcu20140122
磁性介孔纳米粒子的制备及对抗癌药紫杉醇的传输
Fabrication and TXL Anti-cancer Drug Delivery of Magnetic Mesoporous Silica Nanoparticles
摘要
Abstract
Magnetic Fe3 O4@ SiO2 mesoporous silica nanoparticles(MSNs) were synthesized with Fe3 O4 nano-particles as crystal core, cetyltrimethylammium bromide( CTAB) as structural directional agent through the hydrolysis of tetraethoxysilane(TEOS) and self-assembly procedure under the basic conditions. The synthe-sized MSNs were characterized via the XRD, FTIR, TEM and N2 adsorptiom-desorption. The results show that these MSNs have high sepcific surface area of 932 cm2 / g, particles size of 150 nm and typical hexagonal packing mesoporous structure. Simultaneously, all Fe3 O4 nanoparticles are perfectly embedded in silica bulk. As a TXL carrier, Fe3 O4 @ SiO2 exhibits good adsorption with the maximum adsorption capacity of 80 mg / g and TXL-Fe3 O4@ SiO2 has a more than 120 h sustained release for TXL with accumulative quantity of 30 mg /g. While the release behaviour is controlled by various pH values. Higher the pH is, larger the accumulative release is. Experiments of cytotoxicity on HeLa cells indicate that the Fe3 O4@ SiO2 particles exhibit excellent biocompatibility. TXL-Fe3 O4@ SiO2 shows significant inhibition effect on HeLa cells than bare TXL under the same drug concentration.关键词
磁性介孔纳米粒子/紫杉醇/抗癌药物传输/HeLa 细胞/Fe3 O4 纳米粒子Key words
Magnetic mesoporous nanoparticles/Paelitaxel( TXL)/Anticancer drug delivery/HeLa cell/Fe3 O4 nanoparticles分类
化学化工引用本文复制引用
张卓琦,耿浩然,宣瑞飞,陈敏敏,陈辉,刘爱辉,曹希传..磁性介孔纳米粒子的制备及对抗癌药紫杉醇的传输[J].高等学校化学学报,2014,(7):1509-1514,6.基金项目
国家自然科学基金(批准号:30800219)、中国矿业大学理科专项基金(批准号：LK0303)和江苏省介入医疗器械研究重点实验室开放基金(批准号：jr1105)资助. Supported by the National Natural Science Foundation of China( No.30800219), the China University of Mining Science Special Fund (No. LK0303) and the Interventional Medical Devices Key Laboratory Funded Research Projects of Jiangsu Province, China(No. jr1105) （批准号:30800219）
