高等学校化学学报Issue(12)：2567-2579,13.DOI:10.7503/cjcu20140395
N-取代肌肽酰胺类衍生物的合成及生物活性
Synthesis and Biological Activity of N-substituted Carnosine Amide Derivatives
摘要
Abstract
A series of carnosine derivatives were synthesized by modification of primary amino groups of carnosine, eleven target compounds were obtained and characterized by NMR, UV-Vis and HR-MS. Acrolein scavenging activity test results showed that most compounds exhibited some acrolein scavenging activities, es-pecially compound 4k showed the highest acrolein scavenging activity which was stronger than carnosine. Spleen cell proliferation test results showed that most compounds exhibited some spleen cell proliferation activi-ties, compounds 4b, 4d and 4k showed stronger spleen cell proliferation activities than the positive control conA. Hydrogen peroxide injury pre-protection results showed that most compounds exhibited some pre-protec-tion effects, especially compounds 4a, 4j and 4k showed stronger ECV-304 cell pre-protection effects than carnosine. Plasma stability assay results showed that compared with carnosine, eleven compounds had good plasma stability.关键词
肌肽衍生物/丙烯醛清除/脾细胞增殖/过氧化氢损伤预保护/血浆稳定性Key words
Carnosine derivative/Acrolein scavenging/Spleen cell proliferation/Hydrogen peroxide injury protection/Plasma stability分类
化学化工引用本文复制引用
臧皓,孙佳明,黄晓光,纪扬,代婷婷,高晓晨,李晓东,张辉..N-取代肌肽酰胺类衍生物的合成及生物活性[J].高等学校化学学报,2014,(12):2567-2579,13.基金项目
国家自然科学基金(批准号:81373936)、吉林省科技发展计划项目(批准号:20140203015YY)和吉林省教育厅“双十”培育项目(批准号:吉教科合字[2014]第71号)资助.覮 Supported by the National Natural Science Foundation of China(No.81373936), the Science and Technology Development Funds of Jilin Province, China(No.20140203015YY) and the “Double Ten” Development Project of Jilin Province Department of Education, China(No. Ji-JiaoKeHeZi[2014]No.71) （批准号:81373936）
