高等学校化学学报Issue(4)：660-664,5.DOI:10.7503/cjcu20141016
催化量碘代烷烃促进下合成3,5-二取代异噁唑啉
Synthesis of 3,5-Disubstituted Isoxazolines Mediated by Catalytic Alkyl Iodide
摘要
Abstract
A new method for the preparation of 3 , 5-disubstituted isoxazolines using a catalytic amount of 1-iodopropane was developed and the optimization of the reaction conditions was obtained. The possible mechanism for the cycloaddition was suggested as followed:1-iodopropane was first oxidized by oxone into the hypervalent iodine intermediate, then it decomposed at once to form hypoiodous acid, the in situ generated hypoiodous acid reacted with oxime and alkene, and after an elimination of HI, the reaction provided the desired isoxazoline. The new method has some advantages such as mild reaction conditions, simple procedure and good yields.关键词
异噁唑啉/次碘酸/碘代烷烃/催化氧化反应Key words
Isoxazoline/Hypoiodous acid/Alkyl iodide/Catalytic oxidation分类
化学化工引用本文复制引用
方应国,朱敏..催化量碘代烷烃促进下合成3,5-二取代异噁唑啉[J].高等学校化学学报,2015,(4):660-664,5.基金项目
国家自然科学基金(批准号:21072176)资助.覮 Supported by the Natural Natural Science Foundation of China(No.21072176) （批准号:21072176）
