高等学校化学学报Issue(6)：1100-1106,7.DOI:10.7503/cjcu20141145
蒽醌类亲脂性阳离子的合成及抗癌活性
Synthesis of Lipiophilic Cations of Anthraquinone and Their Anticancer Activities
摘要
Abstract
Seven emodin quaternary ammonium salts, two aloe emodin quaternary ammonium salts, one water soluble emodin quaternary ammonium as well as a quaternary ammonium salt of α-naphtholbenzein were syn-thesized and the in vitro anticancer activities were tested. Emodin quaternary ammonium salts containing one long carbon chain showed very low anticancer activities, and emodin and aloe emodin quaternary ammonium salts containing two carbon chains exhibited high anticancer activities. Using hydrophilic long chains to replace lipiophilic long carbon chains made emodin quaternary ammonium salts lose anticancer activities. Quaternary ammonium salt ofα-naphtholbenzein showed a moderate anticancer activity, which indicated that the introduc-tion of lipiophilic cations to a molecule with ability to transfer electrons could increase its anticancer activity.关键词
大黄素/芦荟大黄素/亲脂性阳离子/抗癌活性Key words
Emodin/Aloe emodin/Lipiophilic cation/Anticancer activity分类
化学化工引用本文复制引用
刘丹,邵敬伟,王文峰,胡秀芳,郑艳艳,潘鹤,罗舒维,洪芳,赵文娜,姜美红,祝云辉..蒽醌类亲脂性阳离子的合成及抗癌活性[J].高等学校化学学报,2015,(6):1100-1106,7.基金项目
国家基础科学人才培养基金(批准号：J1103303)和福建省自然科学基金(批准号:2013J01361)资助 （批准号：J1103303）
