高等学校化学学报Issue(6)：1112-1116,5.DOI:10.7503/cjcu20141126
β-氨基膦酸酯衍生物的合成方法
Synthesis Method of β-Aminophosphonate Derivatives
摘要
Abstract
The Mannich reaction of Ohira-Bestmann reagent andα-amino sulfone was preliminary studied with tetrabutyl ammonium iodide( TBAI) as a phase transfer catalyst. Under the optimal reaction conditions, the Mannich reaction between Ohira-Bestmann reagent and a series α-amino sulfone derived from substituted aro-matic aldehyde can be smoothly achieved. Moderate to good yields(52%—93%) were obtained and the struc-ture of β-aminophosphonate derivatives 5a—5k were confirmed by 1 H NMR, 13 C NMR and MS. By the Man-nich reaction of Ohira-Bestmann reagent and α-amino sulfone, an effective method for the preparation ofβ-amino phosphonate derivatives was developed.关键词
β-氨基膦酸酯衍生物/Mannich反应/α-氨基砜/相转移催化Key words
β-Aminophosphonate derivative/Mannich reaction/α-Amino sulfone/Phase-transfer catalysis分类
化学化工引用本文复制引用
熊珍,季四平,钏永明,蒋琳,袁明龙..β-氨基膦酸酯衍生物的合成方法[J].高等学校化学学报,2015,(6):1112-1116,5.基金项目
云南省教育厅科学研究基金(批准号:2013Z036)和云南民族大学研究生创新基金(批准号:2014YJY78)资助 （批准号:2013Z036）
