广东医学Issue(7)：1012-1016,5.
99mTc-DTPA肾动态显像、简化MDRD方程及CKD-EPI方程评价慢性肾脏病患者肾功能的比较
Comparison of GFR calculation methods：99m Tc-DTPA renal dynamic imaging, abbreviated MDRD and CKD-EPI equations in patients with chronic kidney disease
曾凤伟 1李建芳 1谢良骏 1张峰 1彭小林 1吴春兴 1程木华1
作者信息
- 1. 中山大学附属第三医院核医学科 广州510630
- 折叠
摘要
Abstract
Objective To compare the applications of renal dynamic imaging with 99m Tc-DTPA ( Gates′met-hod), abbreviated MDRD (aMDRD) equation and CKD-EPI equation in renal function assessment in the patients with chronic kidney disease ( CKD) .Methods A total of 159 adult patients with CKD were included .The glomerular filtra-tion rate (GFR) obtained by Gates′method, aMDRD equation and CKD-EPI equation against 99mTc-DTPA dual plasma clearance ( rGFR) with Pearson correlational analyses and Bland -Altman method were performed .Results A statistical-ly significant correlation was found between rGFR and Gates′method (r=0.900, P<0.001), which was higher than aM-DRD formula (r=0.816, P<0.001) and CKD-EPI formula (r=0.825, P<0.001).Bland-Altman analysis showed that all equations underestimated the rGFR in the overall performance , but Gates′method had less bias [ -3.4 mL/( min· 1.73 m2 ) ] , good precision [ 11.8 mL/( min · 1.73 m2 ) ] , and greatest accuracy within ±30% of rGFR (71.7%) than aMDRD and CKD-EPI equations.In each stage of CKD, excepting patients in Stage 1 Stage 2, a statisti-cally significant higher accuracy within ±30%was found of the Gates′method compared to the accuracy of the aMDRD formula or CKD-EPI formula (P<0.05).No difference between the accuracies of the aMDRD formula and the CKD -EPI formula was found (P>0.05).Conclusion All three methods underestimate the rGFR, the new CDK-EPI equa-tion performs no better than aMDRD equation .Both equations can′t provide as much accuracy as Gates′method.关键词
肾小球滤过率/肾动态显像/简化MDRD方程/CKD-EPI方程/双血浆法Key words
glomerular filtration rate/renal dynamic imaging/abbreviated MDRD equation/CKD-EPI equa-tion/dual plasma sample method引用本文复制引用
曾凤伟,李建芳,谢良骏,张峰,彭小林,吴春兴,程木华..99mTc-DTPA肾动态显像、简化MDRD方程及CKD-EPI方程评价慢性肾脏病患者肾功能的比较[J].广东医学,2014,(7):1012-1016,5.
