广东医学Issue(13)：1982-1986,5.
6种明胶胶囊药壳对小鼠骨髓细胞微核率的影响
The effects of six medicinal gelatin capsule shells on the micronucleus rates in mouse bone marrow cells
摘要
Abstract
Objective To study the mutagenic effect of six medicinal gelatin capsule shells, and to provide ex-perimental data on the safety of gelatin empty capsules.Methods The mice were given with four different doses of six gelatin capsule shells.The micronucleus rate of mouse bone marrow cells was detected using micronuclear test, and the liver pathological changes were subsequently observed by optical microscope.Results No significant increase in the mi-cronucleus rates was observed in mice with 6 medicinal gelatin capsule shells at the adult′s doses or 100 times of the adult′s doses (P>0.05);only at 200, 400 and 800 times the adult′s dose of 3 gelatin capsule shells there were significant im-pacts on the micronucleus rate ( P<0.05, P<0.01) .However, there was no significant change in the liver pathological observation by all the 6 medicinal gelatin capsule shells.Conclusion These six gelatin capsule shells do not induce genotoxic chromosomal damage at the adult′s doses or lower doses, however, it should be paid attention that three kinds of the six gelatin capsule shells had the potential to cause chromosomes breaking at the medium or high doses.Thus, it′s im-portant to choose quality medicine capsule shell for industry.关键词
明胶胶囊药壳/微核/嗜多染红细胞Key words
medicinal gelatin capsule shells/micronucleus/polychromatic erythrocytes引用本文复制引用
覃默,韦美艳,周芹,方玲,韦力嘉,郑茳尧..6种明胶胶囊药壳对小鼠骨髓细胞微核率的影响[J].广东医学,2015,(13):1982-1986,5.基金项目
广西壮族自治区大学生创新创业训练计划项目 （）
