首页|期刊导航|国际肝胆胰疾病杂志（英文版）|Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress
Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress
Vinicius Rocha-Santos Estela RR Figueira Joel A Rocha-Filho Ana MM Coelho Rafael Soraes Pinheiro Telesforo Bacchella Marcel CC Machado Luiz AC D'Albuquerque
国际肝胆胰疾病杂志（英文版）Issue(2)：194-200,7.
国际肝胆胰疾病杂志（英文版）Issue(2)：194-200,7.DOI:10.1016/S1499-3872(15)60348-4
Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress
摘要
Abstract
BACKGROUND:Liver ischemia reperfusion (IR) injury trig-gers a systemic inlfammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver surgery. Pentoxifylline (PTX) and hypertonic saline solution (HTS) have been identiifed to have beneifcial effects against IR injury. This study aimed to investigate if the addi-tion of PTX to HTS is superior to HTS alone for the preven-tion of liver IR injury. <br> METHODS:Male Wistar rats were allocated into three groups. Control rats underwent 60 minutes of partial liver ischemia, HTS rats were treated with 0.4 mL/kg of intravenous 7.5%NaCl 15 minutes before reperfusion, and HPTX group were treated with 7.5% NaCl plus 25 mg/kg of PTX 15 minutes be-fore reperfusion. Samples were collected after reperfusion for determination of ALT, AST, TNF-α, IL-6, IL-10, mitochondrial respiration, lipid peroxidation, pulmonary permeability and myeloperoxidase. <br> RESULTS:HPTX signiifcantly decreased TNF-α 30 minutes after reperfusion. HPTX and HTS signiifcantly decreased ALT, AST, IL-6, mitochondrial dysfunction and pulmonary myelo-peroxidase 4 hours after reperfusion. Compared with HTS only, HPTX signiifcantly decreased hepatic oxidative stress 4 hours after reperfusion and pulmonary permeability 4 and 12 hours after reperfusion. <br> CONCLUSION:This study showed that PTX added the beneifcial effects of HTS on liver IR injury through decreases of hepatic oxidative stress and pulmonary permeability.关键词
pentoxifylline/hypertonic saline solution/hepatic oxidative stress/ischemia reperfusion injury/pulmonary permeabilityKey words
pentoxifylline/hypertonic saline solution/hepatic oxidative stress/ischemia reperfusion injury/pulmonary permeability引用本文复制引用
Vinicius Rocha-Santos,Estela RR Figueira,Joel A Rocha-Filho,Ana MM Coelho,Rafael Soraes Pinheiro,Telesforo Bacchella,Marcel CC Machado,Luiz AC D'Albuquerque..Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress[J].国际肝胆胰疾病杂志（英文版）,2015,(2):194-200,7.基金项目
This study was supported by a grant from S?o Paulo Foundation Research FAPESP 2011/05214-3 （）
