国际医药卫生导报Issue(15)：2125-2128,4.DOI:10.3760/cma.j.issn.1007-1245.2015.15.007
mmp-14和CD34在青年乳腺癌演变过程中的表达及意义
Expressions of matrix metalloproteinases-14 and CD34 in evolution of breast cancer in youth and its clinical signiifcance
摘要
Abstract
Objective To study the expressions of matrix metalloproteinases-14 (mmp-14) and CD34 in breast cancer, breast benign tumor, mammary gland hyperplasia, and para-carcinoma tissue in patients not over 35 years old and its clinical signiifcance. Methods Immunohistochemical method is used to detect theexpressions of mmp-14 in the terminal breast ducts and acini epithelial cells in 30 patients with breast cancer, 30 with breast benign tumor, 30 with mammary hyperplasia, and 30 with para-carcinoma tissue. And the interstitial blood vessel number marked by CD34 is counted at the same time.ResultsThe expression of mmp-14 was significantly higher in breast cancer than in the other three groups (P<0.05). The expression of CD34 and the number of interstitial blood vessels marked by CD34 were signiifcantly higher in breast cancer and mammary gland hyperplasia than in breast benign tumor (P<0.05).ConclusionsThe high expression of mmp-14 in terminal breast ducts and acini epithelial cells and the increase in interstitial blood vessel number marked by CD34 correlate with the evolution of breast cancer in youth could be used for early diagnosis and clinical reliable indicators for the treatment of breast cancer in youth.关键词
基质金属蛋白酶-14/CD34/免疫组织化学/乳腺癌/青年Key words
Matrix metalloproteinases-14/CD34/Immunohistochemical/Breast cancer/Youth引用本文复制引用
王倩,何利珍,罗凯,劳淑贞,王敏,张琼,侯敏,谭小军,朴金松,高蔚樱..mmp-14和CD34在青年乳腺癌演变过程中的表达及意义[J].国际医药卫生导报,2015,(15):2125-2128,4.基金项目
广州市医药卫生科技项目 （）
