国际医药卫生导报Issue(15)：2233-2235,3.DOI:10.3760/cma.j.issn.1007-1245.2015.15.045
右美托咪啶在慢性阻塞性肺疾病急性加重期患者脱机后镇静作用临床研究
Sedative effect of dexmedetomidine for patients with chronic obstructive pulmonary disease in acute exacerbation period after weaning from mechanical ventilation
李远华 1戚应静 1吴苏华 1赖志君 1谢树锋1
作者信息
- 1. 523320 东莞，广东医学院附属石龙博爱医院重症监护室
- 折叠
摘要
Abstract
Objective To investigate the feasibility and safety of dexmedetomidine for patients with chronic obstructive pulmonary disease in acute exacerbation period (AECOPD) after being weaned from mechanical ventilation.Methods 36 patients with AECOPD after being successfully weaned from mechanical ventilation over 12 hours were given dexmedetomidine in a loading dose 1.0 μg/kg and a maintenance dose of 0.2-0.7 μg/(kg•h). The scores of the depth of Ramsay sedation in all the patients were kept within 3-4 points. 30 minutes and 1, 3, and 6 hours after drug administration, the systolic blood pressure, diastolic blood pressure, heart rate, breathing rate, pulse oxygen saturation, blood gas analysis were detected.Results 30 minutes and 1, 3, and 6 hours after drug administration, the heart rate and systolic and diastolic blood pressures markedly decreased (P < 0.05) and PCO2 didn’t signiifcantly changed (P > 0.05). The arterial blood oxygen partial pressure (PaO2) was signiifcantly higher 6 hours than 0 minute after being weaned from mechanical ventilation (P<0.05). Conclusions Dexmedetomidine for patients with AECOPD after being weaned from mechanical ventilation in ICU doesn’t have signiifcant respiratory depression and no carbon dioxide retention and slightly lowers blood pressure and heart rate.关键词
右美托咪啶/慢性阻塞性肺疾病急性加重期/二氧化碳/镇静Key words
Dexmedetomidine/Chronic ob-structive pulmonary disease in acute exacerbation period/Carbon dioxide/Sedation引用本文复制引用
李远华,戚应静,吴苏华,赖志君,谢树锋..右美托咪啶在慢性阻塞性肺疾病急性加重期患者脱机后镇静作用临床研究[J].国际医药卫生导报,2015,(15):2233-2235,3.
